Tumor necrosis factor-α: a key contributor to intervertebral disc degeneration
نویسندگان
چکیده
منابع مشابه
incidence of microscopic lumbar intervertebral disc calcification and its correlation to endplate degeneration type and disc histopathologic angiogensis
چکیده ندارد.
15 صفحه اولIntervertebral Disc Dynamics and Degeneration
Degenerative disc disease is a serious health problem worldwide, whose etiological basis – mechanical stimulus, biochemical changes, or natural aging – is poorly understood. While the disc’s known function is that of dynamic shock absorber, its dynamic response has not been fully characterized throughout the disc health spectrum (from healthy to degenerate). Therefore, this study aimed to corre...
متن کاملDegeneration of the intervertebral disc
The intervertebral disc is a cartilaginous structure that resembles articular cartilage in its biochemistry, but morphologically it is clearly different. It shows degenerative and ageing changes earlier than does any other connective tissue in the body. It is believed to be important clinically because there is an association of disc degeneration with back pain. Current treatments are predomina...
متن کاملAttenuation of inflammatory events in human intervertebral disc cells with a tumor necrosis factor antagonist.
STUDY DESIGN The inflammatory responses of primary human intervertebral disc (IVD) cells to tumor necrosis factor α (TNF-α) and an antagonist were evaluated in vitro. OBJECTIVE To investigate an ability for soluble TNF receptor type II (sTNFRII) to antagonize TNF-α-induced inflammatory events in primary human IVD cells in vitro. SUMMARY OF BACKGROUND DATA TNF-α is a known mediator of inflam...
متن کاملDisc in flames: Roles of TNF-α and IL-1β in intervertebral disc degeneration.
The intervertebral disc is an important mechanical structure that allows range of motion of the spinal column. Degeneration of the intervertebral disc--incited by aging, traumatic insult, genetic predisposition, or other factors--is often defined by functional and structural changes in the tissue, including excessive breakdown of the extracellular matrix, increased disc cell senescence and deat...
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ژورنال
عنوان ژورنال: Acta Biochimica et Biophysica Sinica
سال: 2016
ISSN: 1672-9145,1745-7270
DOI: 10.1093/abbs/gmw112